Dna Content—A Prognostic Factor in Childhood Medulloblastoma?
نویسندگان
چکیده
منابع مشابه
Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients.
BACKGROUND Medulloblastomas are the most common primary malignant childhood intracranial neoplasms. Patients are currently sorted into three risk groups based on clinical criteria: standard, poor, and infant (<18 months old). We hypothesized that genetic copy number aberrations (CNA) predict prognosis and would provide improved criteria for predicting outcome. METHODS DNA from 35 medulloblast...
متن کاملChildhood medulloblastoma.
Among all the childhood central nervous system tumours, medulloblastoma and other neuroectodermal tumours account for 16-25% of cases. The causative factors of medulloblastoma/PNET have not been well established. It is more frequent in boys than in girl and in children than in adults. There was a significant improvement of survival for children diagnosed in 2000-2002 compared to those diagnosed...
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A number of studies have shown that the DNA-ploidy of mononucleated blood cells is a prognostic factor of acute lymphoblastic leukaemia in childhood, patients with an hyperploid DNA index showing a significantly better response to chemotherapy than those with a euploid DNA index. The aim of the present study was to re-evaluate this question for a subset of patients in the German-Austrian-Swiss ...
متن کاملIntracranial calcification in survivors of childhood medulloblastoma.
Computerised tomography scans of the brain have been performed on 5 children who have survived at least 5 years after treatment with surgery and radiotherapy for medulloblastoma. Intracranial calcification of varying degrees of the basal ganglia and of the frontal and parietal cortex was detected in the 3 children who were irradiated under age 5 years.
متن کاملMetastatic Medulloblastoma in Childhood: Chang's Classification Revisited
Purpose. To correlate the radiological aspects of metastases, the response to chemotherapy, and patient outcome in disseminated childhood medulloblastoma. Patients and Methods. This population-based study concerned 117 newly diagnosed children with disseminated medulloblastoma treated at the Institute Gustave Roussy between 1988 and 2008. Metastatic disease was assessed using the Chang staging ...
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ژورنال
عنوان ژورنال: Acta Oncologica
سال: 1993
ISSN: 0284-186X,1651-226X
DOI: 10.3109/02841869309092454